Sulfobutylated beta-cyclodextrin sodium salt (DS~6.5)

(CODE: 47)

Abbreviation: SBECD

CAS Number: 182410-00-0

Product Number: 47

Cyclodextrin type: Anionic cyclodextrins

Quality: Research grade

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Chemical and Physical Description

Average Molecular Formula	C₄₂H_70-nO₃₅ · (C₄H₈O₃SNa)_n
Average Formula Weight	1135.0 + n·(158.2)
Possible impurities	4-Hydroxybutane-1-sulfonic acid sodium salt, bis(4-sulfobutyl) ether disodium, residual BCD
Solubility (in 100 cm³ solvent, at 25 °C)	Water: > 50 g Methanol: < 0.5 g Acetone: < 0.5 g

Specification

Test	Method	Range
Appearance	Visual	white or off-white powder
Identification A	IR (USP <197>)	complies with SBECD reference
Identification B (assay method)	HPLC (USP <621>)	t_R of major peak complies with SBECD reference
Identification C	Sodium ID (USP <191>)	positive test
Assay	HPLC (USP <621>)	95.0 - 105.0% on the anhydrous basis
Heavy metals	EP 2.4.8 B	NMT 10 ppm
Limit of related substances BCD (Betadex) total other impurities	HPLC (USP <621>)	NMT 0.1% NMT 1.0%
Limit of 1,4-butane sultone	GC (USP <621>)	NMT 1 ppm
Limit of 4-hydroxybutane-1-sulfonic acid	CE (USP <1053>)	NMT 0.09%
Limit of bis(4-sulfobutyl) ether disodium	CE (USP <1053>)	NMT 0.05%
Clarity of solution (30%, w/v)	Visual, see details in the USP Monograph	the solution is clear, and essentially free from particles of foreign matter
Average Degree of Substitution (n)	CE (USP <1053>)	6.2 - 6.9
Limit of sodium chloride	Limit test (USP <221>)	NMT 0.2%
Residual solvents: ethanol	GC (USP <621>)	NMT 2500 ppm
pH (30%, w/v)	USP <791>	4.0 - 6.8
Water content	USP <921> Method I	NMT 10.0%

Comments: only for reagent and laboratory purposes, not for human use.

Storage: at room temperature, in tightly closed container.

MSDS Downloads

47-SBECD