Beta-cyclodextrin

(CODE: 33)


Abbreviation: BCD
CAS Number: 7585-39-9
Product Number: 33
Cyclodextrin type: Native, neutral
Quality: pharma grade
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Chemical and Physical Description
Molecular Formula C42H70O35
Formula Weight 1135.0
Possible impurities Other cyclodextrins, linear oligomers
Solubility
(in 100 cm3 solvent, at 25 °C)		 Water: < 2.0 g
Methanol: < 1.0 g
DMSO: > 10 g
Specification
Test Method Range
Appearance Visual white or almost white powder
Identification A: Specific optical rotation EP 2.2.7 +160° to +164°
Identification B: HPLC EP 2.2.29 conforms with reference
Identification C: Iodine test   yellow-brown precipitate
Appearance of 1% aqueous solution Visual (EP 2.2.1) clear and colorless solution
pH of 1% aqueous solution EP 2.2.3 5.0 - 8.0
Reducing sugars   max. 0.2%
Light absorbing impurities (1%) UV-Vis (EP 2.2.25) A230 - A350: max. 0.10
A350 - A750: max. 0.05
Related substances
residual ACD
residual GCD
sum of other impurities		 HPLC (EP 2.2.29)
max. 0.25%
max. 0.25%
max. 0.50%
Residual solvents GC (EP 2.2.28) max. 10 ppm trichloroethylene
max. 10 ppm toluene
Heavy metals EP 2.4.20 Cd  max. 0.2 ppm
Pb  max. 0.5 ppm
As  max. 1.5 ppm
Hg  max. 0.3 ppm
Co max. 0.5 ppm
V   max. 1 ppm
Ni  max. 2 ppm
Sulphated ash EP 2.4.14 max. 0.1%
BCD content HPLC (EP 2.2.29) 98.0 - 101.0%
Microbial contamination EP 2.6.12, EP 2.6.13 TAMC: <103 CFU/g
TYMC: <102 CFU/g
Salmonella: absent/10 g
E. Coli: absent/1 g
Loss on drying EP 2.2.32 max. 16.0%
Storage: at room temperature, in tightly closed container.

MSDS Downloads

  • MSDS_CY_2001_BCDv2.5

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