(2-Hydroxypropyl)-beta-cyclodextrin (DS~4.5)

(CODE: 27)


Abbreviation: HPBCD
CAS Number: 128446-35-5
Product Number: 27
Cyclodextrin type: Randomly substituted cyclodextrins, neutral
Quality: pharma grade
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Chemical and Physical Description
Average Molecular Formula C42H70-nO35 · (C3H7O)n
Average Formula Weight 1135.0 + n·(58.1)
Possible impurities Propylene glycol, beta-cyclodextrin, hydroxypropylated linear dextrins
Solubility
(in 100 cm3 solvent, at 25 °C)		 Water: > 33 g
Methanol: > 33 g
DMF: > 33 g
Specification
Test Method Range
Appearance Visual white or almost white, amorphous or crystalline powder
Identification A IR (EP 2.2.24) complies with reference standard
Identification B  (Appearance of solution) EP 2.2.1, EP 2.2.2 Method II 1 g dissolved in 2 mL of water with heating is clear and colorless and remains so after cooling
Conductivity (25 °C, 1% solution in water) EP 2.2.38 max. 200 µS/cm
Related substances
residual BCD
propylene glycol
total other impurities
HPLC (EP 2.2.29)
GC (EP 2.2.28)
HPLC (EP 2.2.29)
max. 1.5%
max. 2.5%
max. 1.0%
Heavy metals EP 2.4.20 Cd  max. 0.2 ppm
Pb  max. 0.5 ppm
As  max. 1.5 ppm
Hg  max. 0.3 ppm
Co max. 0.5 ppm
V   max. 1 ppm
Ni  max. 2 ppm
Average Degree of Substitution (n) NMR (EP 2.2.33) 2.8 - 10.5 (molar substitution: 0.4 - 1.5)
Microbial contamination EP 2.6.12, EP 2.2.13 TAMC: max. 103 CFU/g
TYMC: max. 102 CFU/g
Salmonella: absent/10 g
E.Coli: absent/1 g
Bacterial endotoxin (if intended for parenteral use) EP 2.6.14 <10 IU/g
Loss on drying EP 2.2.32 max. 10.0%
Storage: at room temperature, in tightly closed container.

MSDS Downloads

  • MSDS_CY_2005_HPBCDv2.4

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