(2-Hydroxypropyl)-gamma-cyclodextrin (DS~4.5)

(CODE: 38)


Abbreviation: HPGCD
CAS Number: 128446-34-4
Product Number: 38
Cyclodextrin type: Randomly substituted cyclodextrins, neutral
Quality: standard grade
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Chemical and Physical Description
Average Molecular Formula C48H80-nO40 · (C3H7O)n
Average Formula Weight 1297.2 + n·(58.1)
Possible impurities Propylene glycol, GCD, hydroxypropylated linear dextrins
Solubility
(in 100 cm3 solvent, at 25 °C)		 Water: > 50 g
Methanol: > 50 g
Chloroform: < 1.0 g
Specification
Test Method Range
Appearance Visual white or off-white powder
Specific rotation EP 2.2.7 145° – 165°
Clarity of solution (1 g in 2 ml)   clear and colorless solution
Related substances:
GCD
propylene glycol
HPLC (EP 2.2.29)
GC (EP 2.2.28)
max. 1.0%
max. 1.0%
Residual solvents:
methanol
acetone		 GC (EP 2.2.28)

 
max. 50 ppm
max. 50 ppm
Heavy metals EP 2.4.8 max. 20 ppm
pH (2% in water)   6.0-9.0
Average Degree of Substitution (n) NMR (EP 2.2.33) 3.2 - 5.6
Water content EP 2.5.12 max. 7.0%
Light absorbing impurities (5%)
 		 EP 2.2.25
 		 max. 1.0 (220 – 350 nm)
max. 0.1 (350 – 600 nm)
Comments: only for reagent and laboratory purposes, not for human use.

Storage: at room temperature, in tightly closed container.

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  • 38-HPGCD

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    (2-Hydroxypropyl)-gamma-cyclodextrin
    (CODE: 38)
    Quality: pharma grade
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