(2-Hydroxypropyl)-beta-cyclodextrin (DS~4.5) secondary standard

(CODE: )

Price: € 100.00 / g

Abbreviation: HPBCD WS
CAS Number: 128446-35-5
Product Number:
Cyclodextrin type: Randomly substituted cyclodextrins, neutral
Quality: analytical standard
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Complies with EP and USP Pharmacopoeia requirements.

Chemical and Physical Description
Average Molecular Formula C42H70-nO35 · (C3H7O)n
Average Formula Weight 1135.0 + n·(58.1)
Possible impurities Propylene glycol, beta-cyclodextrin, hydroxypropylated linear dextrins
Solubility
(in 100 cm3 solvent, at 25 °C)
Water: > 33 g
Methanol: > 33 g
DMF: > 33 g
Specification
Test Method Range
Appearance Visual white or almost white, amorphous or crystalline powder
Identification A IR EP 2.2.24, USP<197K) complies with reference standard
Identification B   Appearance of solution,
EP 2.2.1, EP 2.2.2 Method II and as in USP monograph
1 g dissolved in 2 mL of water with heating is clear and colorless and remains so after cooling
Conductivity (25 °C, 1% solution in water) EP 2.2.38 max. 200 µS/cm
Related substances
residual BCD
propylene glycol
total other impurities

HPLC EP 2.2.29, USP<621>
GC EP 2.2.28, USP<621>
HPLC EP 2.2.29, USP<621>

max. 1.5%
max. 2.5%
max. 1.0%
Heavy metals EP 2.4.8 max. 20 ppm
Elemental impurities USP<231> Cadmium         NMT 0.2 µg/g
Lead                    NMT 0.5 µg/g
Arsenic             NMT 1.5 µg/g
Mercury           NMT 0.3 µg/g
Average Degree of Substitution (n) NMR EP 2.2.33, USP<761> 2.8 - 10.5 (molar substitution: 0.4 - 1.5)
Loss on drying EP 2.2.32, USP<731> max. 10.0%
Storage: at room temperature, in tightly closed container.

MSDS Downloads

  • CY2005-HPBCD

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