(2-Hydroxypropyl)-beta-cyclodextrin (DS~4.5) secondary standard

(CODE: -)

Price: € 115.76 / g

Abbreviation: HPBCD WS

CAS Number: 128446-35-5

Product Number: -

Cyclodextrin type: Randomly substituted, non-ionic

Quality: Analytical standard grade

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Volume	Volume Discount	Price
from 1 g	0%	€ 115.76 / g

Complies with EP and USP Pharmacopoeia requirements.

Chemical and Physical Description

Average Molecular Formula	C₄₂H_70-nO₃₅ · (C₃H₇O)_n
Average Formula Weight	1135.0 + n·(58.1)
Possible impurities	Propylene glycol, beta-cyclodextrin, hydroxypropylated linear dextrins
Solubility (in 100 cm³ solvent, at 25 °C)	Water: > 33 g Methanol: > 33 g DMF: > 33 g

Specification

Test	Method	Range
Appearance	Visual	white or almost white, amorphous or crystalline powder
Identification A	IR EP 2.2.24, USP<197K)	complies with reference standard
Identification B	Appearance of solution, EP 2.2.1, EP 2.2.2 Method II and as in USP monograph	1 g dissolved in 2 mL of water with heating is clear and colorless and remains so after cooling
Conductivity (25 °C, 1% solution in water)	EP 2.2.38	max. 200 µS/cm
Related substances residual BCD propylene glycol total other impurities	HPLC EP 2.2.29, USP<621> GC EP 2.2.28, USP<621> HPLC EP 2.2.29, USP<621>	max. 1.5% max. 2.5% max. 1.0%
Heavy metals	EP 2.4.8	max. 20 ppm
Elemental impurities	USP<231>	Cadmium NMT 0.2 µg/g Lead NMT 0.5 µg/g Arsenic NMT 1.5 µg/g Mercury NMT 0.3 µg/g
Average Degree of Substitution (n)	NMR EP 2.2.33, USP<761>	2.8 - 10.5 (molar substitution: 0.4 - 1.5)
Loss on drying	EP 2.2.32, USP<731>	max. 10.0%