(2-Hydroxypropyl)-beta-cyclodextrin (DS~4.5)

(CODE: 27)

Abbreviation: HPBCD
CAS Number: 128446-35-5
Product Number: 27
Cyclodextrin type: Randomly substituted cyclodextrins, neutral
Quality: standard grade
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Chemical and Physical Description
Average Molecular Formula C42H70-nO35 · (C3H7O)n
Average Formula Weight 1135 + n·(58.1)
Possible impurities Propylene glycol, BCD, hydroxypropylated linear dextrins
(in 100 cm3 solvent, at 25 °C)
Water: > 33 g
Methanol: > 33 g
DMF: > 33 g
Test Method Result
Appearance Visual white or almost white powder
Appearance of 1% aqueous solution Visual (EP 2.2.1, EP 2.2.2) Method II 1 g dissolved in 2 mL of water with heating is clear and colorless and remains so after cooling
Identification 1 IR (EP 2.2.24) complies with reference
Identification 2 HPLC (EP 2.2.29) retention time complies with reference standard
Purity Calculated
(on dry substance)
min. 96%
Average Degree of Substitution (n) NMR (EP 2.2.33) 2.0 - 6.0
Residual BCD HPLC (EP 2.2.29) max. 2.0%
Propylene glycol content GC (EP 2.2.28) max. 2.5%
Sulphated ash EP 2.4.14 max. 1.0%
Loss on drying EP 2.2.32 max. 7.5%
Comments: only for reagent and laboratory purposes, not for human use.

Storage: at room temperature, in tightly closed container.

MSDS Downloads


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