(2-Hydroxypropyl)-alpha-cyclodextrin (DS~4.5)

(CODE: 41)

Abbreviation: HPACD

CAS Number: 99241-24-4

Product Number: 41

Cyclodextrin type: Randomly substituted cyclodextrins, neutral

Quality: Research grade

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Chemical and Physical Description

Average Molecular Formula	C₃₆H_60-nO₃₀ · (C₃H₇O)_n
Average Formula Weight	972.9 + n·(58.1)
Possible impurities	Propylene glycol, ACD, hydroxypropylated linear dextrins
Solubility (in 100 cm³ solvent, at 25 °C)	Water: ~ 50 g Methanol: ~ 5 g (opalescent) Chloroform: < 1 g

Specification

Tests and methods	Requirements
Appearance# / visual	white or off-white powder
Clarity of solution	1 % aqueous solution is clear
Appearance of aqueous solution # / (EP 2.2.1, EP 2.2.2 Method II)	1 g dissolved in 2 ml of water with heating is clear and colorless and remains so after cooling
Conductivity ( EP 2.2.38)	< 200 µS/cm
Light absorbing impurities UV-VIS	A_220-350nm: max. 0.1 A_350-600nm: max. 0.01
MS (Molar substitution)* / NMR (EP 2.2.33)	0.5-0.9
Propylene glycol / GC (EP 2.2.28)	max. 0.5%
Loss on drying# / (EP 2.2.32)	max. 10.0%
Residual αCD / HPLC (EP 2.2.29)	max. 1.5%
pH# (EP 2.2.3)	5.0-8.0

* MS: number of hydroxypropyl groups / anhydroglucose units
# tests to extend expiry

Storage: in well-closed container at room temperature.
Expiry/retest date: 36 months from date of qualification.

Comments: only for reagent and laboratory purposes, not for human use.

MSDS Downloads

CY1005-HPACD